Make the vanilla cake mix and the Devil's Food cake mix according to package directions. Divide and pour the vanilla cake batter into 2 12-cup muffin tins, then divide and pour the Devil's Food cake batter into 2 other 12-cup muffin tins. You can also work in batches.
While the cupcakes are baking, make the Vanilla Buttercream frosting. Divide the frosting equally into four bowls. Leave one bowl plain white, add blue food coloring to one bowl, red food coloring to another, and black food coloring to the final fourth bowl. Stir each separately until you no longer see white frosting.
When the cupcakes are done baking, allow them to cool completely before frosting. While they are cooling, prep the frosting to pipe as swirls.
Create the swirled frosting effect
Place a section of plastic wrap about 12" x 12" onto your kitchen counter or other flat surface.
Scoop each of the colored frostings into their own piping bag, and cut off a small circle at the end tip of each bag.
In the center of the prepared plastic wrap, pipe a row of white frosting, then a row of blue frosting immediately next to it, and repeat. So you'll have a row of white, row of blue, second row of white, and second row of blue.
Roll the plastic wrap up and around to create a log, then cut off one end and twist up the plastic wrap on the other end. Carefully place the log into a new piping bag that's fitted with a large star tip. Gently press from the top of the bag to pipe the swirled frosting onto the vanilla cupcakes.
Repeat this process with a new sheet of plastic wrap and the red and black frosting. Pipe the swirled red and black frosting onto the Devil's Food cupcakes.
Decorate with color coordinated sprinkles for each if you like.
Notes
Makes approximately 40-48 cupcakes (20-24 of each kind of cupcake)Frosting: you can use our favorite Vanilla Buttercream Frosting recipe or your favorite store-bought frosting.Storage: Store frosted cupcakes in an airtight container at room temperature for up to 3 days. Store unfrosted cupcakes and the frosting separately in the refrigerator for up to 5 days, then allow both to come to room temperature when you are ready to pipe the frosting and serve.